The Question is from neet-botany cell-biology , and it was created by the author Mr. NARESH KUMAR K

Question

Defects in which organelle can lead to Zellweger syndrome, a severe peroxisomal biogenesis disorder?

Mr. NARESH KUMAR K · Accepted Answer

## CORE INFORMATION
✓ **Answer**: D
## CONCEPT FRAMEWORK
 **Primary Concept**: Zellweger syndrome and peroxisome function
 **Related Topics**: Peroxisomal biogenesis disorders, organelle function, genetic disorders
 **Prerequisites**: Basic understanding of cell organelles and their roles.
## SOLUTION PATHWAY
**Given Information**:
  Zellweger syndrome is a severe peroxisomal biogenesis disorder.
  We need to identify the organelle whose defects lead to this syndrome.
**Method & Steps**:
 1. Understand the role of peroxisomes.
  Reasoning: Peroxisomes are organelles responsible for various metabolic processes, including the breakdown of very long-chain fatty acids and the synthesis of specific lipids.
  Formula/Rule: N/A
 2. Relate peroxisome dysfunction to Zellweger syndrome.
  Working: Zellweger syndrome is caused by mutations in genes involved in the assembly and function of peroxisomes.  This leads to impaired peroxisomal biogenesis, meaning the peroxisomes are not properly formed or function correctly.  This results in the accumulation of very long-chain fatty acids and other harmful substances.
  Key Point: The core problem in Zellweger syndrome is a defect in the formation and function of peroxisomes themselves.
 3. Identify the correct organelle.
  Result: Defects in peroxisomes directly cause Zellweger syndrome.
  Verification: The question explicitly states that Zellweger syndrome is a peroxisomal biogenesis disorder.  Therefore, defects in peroxisomes are the cause.
 ## OPTION ANALYSIS
A :x: Lysosomes are involved in waste breakdown, but not directly related to Zellweger syndrome's primary defect.
B :x: The endoplasmic reticulum is involved in protein synthesis and lipid metabolism, but not the primary cause of Zellweger syndrome.
C :x: The Golgi apparatus is involved in protein modification and transport, but not the primary organelle affected in Zellweger syndrome.
D ✓: Peroxisomes are directly implicated in Zellweger syndrome, as their malfunction is the root cause of the disorder.
 ## LEARNING AIDS
 **Common Mistakes**:
  1.Confusing peroxisomes with other organelles: Understanding the unique functions of each organelle is crucial.
   How to avoid: Review the functions of lysosomes, endoplasmic reticulum, Golgi apparatus, and peroxisomes.
  2.Failing to understand the link between gene mutations and organelle dysfunction: Gene mutations can affect the protein machinery that builds and maintains organelles.
   How to avoid: Understand the molecular basis of organelle biogenesis.
 **Quick Tips**:
  1.Remember that Zellweger syndrome is a *peroxisomal* biogenesis disorder.
  2.Associate peroxisomes with very long-chain fatty acid breakdown to easily recall their function.

Mr. NARESH KUMAR K · Answer

Lysosomes

Mr. NARESH KUMAR K · Answer

Endoplasmic reticulum

Mr. NARESH KUMAR K · Answer

Golgi apparatus

Mr. NARESH KUMAR K · Answer

The correct Option is "Peroxisomes"

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