The Question is from neet-botany cell-cycle-and-cell-division , and it was created by the author Mr. NARESH KUMAR K

Question

The cell cycle is regulated by checkpoints.  Which of the following factors might cause a cell to be arrested at the G1/S checkpoint?

Mr. NARESH KUMAR K · Accepted Answer

## CORE INFORMATION
✓ **Answer**: [Option D]
## CONCEPT FRAMEWORK
	**Primary Concept**: Cell cycle regulation through checkpoints
	**Related Topics**: Cell cycle phases, DNA damage response, cellular signaling
	**Prerequisites**: Understanding of the cell cycle phases (G1, S, G2, M) and the role of checkpoints
## SOLUTION PATHWAY
**Given Information**:
		- G1/S checkpoint: A critical control point that assesses the cell's readiness to enter the S phase (DNA synthesis)
		- Factors affecting checkpoint activation
**Method & Steps**:
	1. Assess the role of DNA integrity at the G1/S checkpoint.
		Reasoning: The G1/S checkpoint monitors DNA damage to prevent replication of damaged DNA.
		Formula/Rule: If DNA is damaged, the cell cycle is halted until repair mechanisms are activated.
	2. Evaluate the other options provided.
		Working: Nutrient availability and completed DNA replication are not reasons for arrest at this checkpoint.
		Key Point: Proper spindle fiber attachment is evaluated during the M phase, not G1/S.
	3. Conclude that damaged DNA is a key factor for G1/S arrest.
		Result: The presence of damaged DNA leads to cell cycle arrest.
		Verification: The cell's DNA damage response pathways (e.g., p53 activation) are triggered to halt the cycle.
## OPTION ANALYSIS
[A] :x: Sufficient nutrients allow progression through the G1 phase, not arrest.
[B] :x: Completed DNA replication is assessed at the G2 checkpoint, not G1/S.
[C] :x: Proper spindle fiber attachment is relevant during the M phase, not G1/S.
[D] ✓: Damaged DNA triggers a halt at the G1/S checkpoint to prevent the replication of damaged genetic material.
## LEARNING AIDS
	**Common Mistakes**:
		1. Confusing checkpoint phases: Remember G1/S focuses on DNA integrity, while G2 and M phase checkpoints are about replication and spindle attachment.
		2. Misidentifying factors affecting checkpoints: Review the functions of each checkpoint clearly.
	**Quick Tips**:
		1. Use mnemonic devices to remember the checkpoints and their functions (e.g., G1 = Growth and DNA check, S = Synthesis, G2 = Growth and preparation for mitosis).
		2. Visualize the cell cycle with diagrams to reinforce the relationships between phases and checkpoints.

Mr. NARESH KUMAR K · Answer

Sufficient nutrients

Mr. NARESH KUMAR K · Answer

Completed DNA replication

Mr. NARESH KUMAR K · Answer

Proper spindle fiber attachment

Mr. NARESH KUMAR K · Answer

The correct Option is "Damaged DNA"

NEET Botany Cell Cycle and Cell Division MCQs

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