The Question is from neet-botany mineral-nutrition deficiency-symptoms, and it was created by the author Mr. NARESH KUMAR K

Question

A patient presents with severe muscle weakness, difficulty walking, and loss of tendon reflexes.  Further investigation reveals impaired glucose metabolism and cardiac abnormalities.  These symptoms are MOST likely associated with a deficiency of:

Mr. NARESH KUMAR K · Accepted Answer

## CORE INFORMATION
✓ **Answer**: C
## CONCEPT FRAMEWORK
	**Primary Concept**: Vitamin Deficiency and Associated Symptoms
	**Related Topics**: Metabolism, Neurology, Cardiology
	**Prerequisites**: Basic understanding of vitamin functions and deficiency syndromes.
## SOLUTION PATHWAY
**Given Information**:
	* Severe muscle weakness
	* Difficulty walking
	* Loss of tendon reflexes
	* Impaired glucose metabolism
	* Cardiac abnormalities
**Method & Steps**:
	1. **Analyze Symptoms**: The combination of muscle weakness, difficulty walking, and loss of tendon reflexes suggests a neurological component.
		Reasoning: These are common manifestations of neurological dysfunction.
	2. **Consider Metabolic and Cardiac Involvement**: Impaired glucose metabolism and cardiac abnormalities point towards a systemic issue, potentially related to energy production.
		Working: Thiamine (Vitamin B1) plays a crucial role in glucose metabolism and cardiac function.
		Key Point:  Thiamine deficiency, often seen in conditions like beriberi, can manifest with these specific neurological and cardiovascular symptoms.
	3. **Connect to Vitamin Deficiency**: Thiamine deficiency (beriberi) aligns with all the presented symptoms.
		Result: Thiamine (Vitamin B1) deficiency is the most likely cause.
		Verification: The symptoms described closely match the classic presentation of beriberi.
## OPTION ANALYSIS
[A] :x: Vitamin D deficiency primarily leads to bone disorders (rickets, osteomalacia) and is not typically associated with the neurological and cardiac symptoms described.
[B] :x: Vitamin B12 deficiency can cause neurological problems (e.g., peripheral neuropathy), but the combination of muscle weakness, loss of reflexes, impaired glucose metabolism, and cardiac abnormalities is more characteristic of thiamine deficiency.
[C] ✓: Thiamine (Vitamin B1) deficiency (beriberi) directly causes the described neurological symptoms (including muscle weakness, difficulty walking, and loss of reflexes) and also impacts glucose metabolism and cardiac function.
[D] :x: Niacin deficiency (pellagra) can cause a range of symptoms (including dermatitis, diarrhea, and dementia), but it doesn't typically present with the specific neurological and cardiac issues described in the question.
## LEARNING AIDS
	**Common Mistakes**:
		1. Focusing solely on the neurological symptoms and overlooking the metabolic and cardiac components:
			How to avoid: Consider the full clinical picture and look for connections between seemingly disparate symptoms.
		2. Confusing B vitamin deficiencies:
			How to avoid: Learn the specific symptoms associated with each B vitamin deficiency.
	**Quick Tips**:
		1. Remember the classic triad of beriberi: muscle weakness, neuropathy, and cardiac involvement.
		2. Associate thiamine with energy production and its crucial role in glucose metabolism.

Mr. NARESH KUMAR K · Answer

Vitamin D

Mr. NARESH KUMAR K · Answer

Vitamin B12

Mr. NARESH KUMAR K · Answer

The correct Option is "Thiamine (Vitamin B1)"

Mr. NARESH KUMAR K · Answer

Niacin

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