A researcher is studying a novel inhibitor that specifically targets the F0 subunit of ATP synthase. What is the most likely direct effect of this inhibitor on aerobic respiration?
Increased electron transport chain activity
Inhibition of proton flow through the inner mitochondrial membrane
Enhanced ATP production
Stimulation of Krebs cycle activity
Related Questions
Which enzyme in the Krebs cycle catalyzes a reaction that directly produces a high-energy phosphate compound without involving an oxidation/reduction reaction?
Succinyl-CoA synthetase
Isocitrate dehydrogenase
α-ketoglutarate dehydrogenase
Malate dehydrogenase
The enzymes for TCA cycle are present in
Plastids
Golgi complex
Mitochondria
Endoplasmic reticulum
In the tricarboxylic acid cycle, which reaction involves a substrate-level phosphorylation rather than an oxidation?
Succinyl-CoA to succinate
Citrate to isocitrate
Fumarate to malate
Isocitrate to α-ketoglutarate
Which specific component of the electron transport chain is directly responsible for the reduction of oxygen to water during aerobic respiration?
NADH dehydrogenase
Succinate dehydrogenase
Cytochrome bc1 complex
Cytochrome c oxidase
All of the following steps in the TCA cycle involve the reduction of or EXCEPT:
Succinyl-CoA to succinate
Isocitrate to α-ketoglutarate
α-ketoglutarate to succinyl-CoA
Malate to oxaloacetate
During aerobic respiration, the complete oxidation of one molecule of glucose theoretically yields 38 ATP. However, the actual yield is often lower. Which of the following is NOT a significant contributor to this reduced ATP yield?
Incomplete oxidation of glucose in the cytoplasm
Leakage of protons across the inner mitochondrial membrane
Utilization of the proton gradient for processes other than ATP synthesis
Variations in the efficiency of the electron transport chain
Which step in the Krebs cycle does NOT involve an oxidation reaction?
Succinyl-CoA to succinate
Isocitrate to α-ketoglutarate
α-ketoglutarate to succinyl-CoA
Malate to oxaloacetate
A researcher is studying a novel inhibitor that specifically targets the F0 subunit of ATP synthase. What is the most likely direct effect of this inhibitor on aerobic respiration?
Increased electron transport chain activity
Inhibition of proton flow through the inner mitochondrial membrane
Enhanced ATP production
Stimulation of Krebs cycle activity
If the inner mitochondrial membrane were to become permeable to protons, what would be the MOST immediate consequence on ATP synthesis?
ATP synthesis would increase due to increased proton flow.
ATP synthesis would stop because the proton gradient would dissipate.
ATP synthesis would be unaffected as it relies on substrate-level phosphorylation.
ATP synthesis would decrease, but some ATP would still be produced by glycolysis.
Under anaerobic conditions, the regeneration of NAD+ for glycolysis is primarily achieved through:
The electron transport chain
Formation of lactate or ethanol
The Krebs cycle
Oxidative phosphorylation
