A patient presents with recurrent infections, severely depleted T-cell counts, and underdeveloped secondary lymphoid organs. Genetic analysis reveals a mutation affecting a specific receptor crucial for thymocyte development. Which receptor is MOST likely mutated, leading to this severe immunodeficiency?
a) IL-7 receptor
b) CXCR4 receptor
c) Notch1 receptor
d) CCR7 receptor
Related Questions
Which of the following is NOT a function of the thymus gland?
Maturation of T cells
Production of thymic hormones
Production of antibodies
Development of immune tolerance
‘Myasthenia gravis’ is related to which hormone?
Thyroid hormone
Calcitonin hormone
Thymosine hormone
Vitamin-D
Thymus gland releases …… hormone
Thymosins
TCT
The thymus gland is a lobular structure located on the …A… side of the …B… and aorta. The thymus plays a significant role in the development …C… system
Choose the correct combination of A, B and C
A-ventral, B-heart, C-immune
A-lateral, B-kidney, C-circulatory
A-dorsal, B-heart, C-immune
A-dorsal, B-parathyroid, C-circulatory
Which one of the following four glands is correctly matched with the accompanying description?
Thyroid — Hyperactivity in young children cause cretinism
Thymus — Starts undergoing atrophy after puberty
Parathyroid — Secretes parathormone, which promotes movements of
Calcium ions from blood into bones during calcification
Pancreas — Delta cells of islets of Langerhans secrete a hormone, which
Stimulates glycolysis in liver
Which of the following statements best describes the function of the thymus gland?
It produces hormones that regulate blood sugar levels.
It matures T lymphocytes, crucial for cell-mediated immunity.
It stores and releases red blood cells.
It secretes digestive enzymes.
Hassall’s bodies/corpuscles are present in
Adrenal medulla
Thyroid
Thymus
Parathyroid
The decline and disappearance of …… gland by the middle age is primary cause of ageing
Thyroid
Thymus
Adrenal
Parathyroid
A child with a weak immune system. Which of the following gland could be the cause of the problem?
Thyroid gland
Parathyroid gland
Thymus
Pituitary gland
Damage to thymus in a child may lead to
A reduction in haemoglobin content of blood.
A reduction in stem cell production.
Loss of antibody- mediated immunity.
Loss of cell- mediated immunity
