The Question is from neet-botany biomolecules-biology introduction, and it was created by the author B VENKAT

Question

Lipid are found in acid insoluble fraction during the analysis of chemical composition of tissues. Given the reason

B VENKAT · Accepted Answer

## CORE INFORMATION
✓ **Answer**: D
## CONCEPT FRAMEWORK
**Primary Concept**:  Cell Fractionation and Solubility of Biomolecules
**Related Topics**:  Lipid Structure, Biomembranes, Tissue Analysis, Centrifugation
**Prerequisites**: Basic knowledge of cell biology, biomolecules, and lab techniques.
## SOLUTION PATHWAY
**Given Information**:
- Lipids are found in the acid-insoluble fraction during tissue analysis.
- The question asks for the reason behind this observation.
**Method & Steps**:
1. **Understanding the process:** Tissue analysis often involves grinding or homogenization to break open cells. This process releases cellular components.
    Reasoning: This step is crucial because it disrupts the cell structure, allowing for the separation of different biomolecules.
2. **Analyzing lipid behavior:** Lipids are primarily found in cell membranes. These membranes are composed of lipids and proteins. When cells are broken, the membranes fragment.
    Working: Lipid molecules, being hydrophobic, tend to aggregate and form vesicles to minimize contact with the aqueous environment.
    Key Point: The key is that the membranes don't dissolve into individual molecules, but rather form insoluble vesicles.
3. **Relating to acid-insoluble fraction**: Because these lipid vesicles are not soluble in the acidic solution used in the cell fractionation process, they precipitate out and end up in the insoluble fraction.
    Result: Option D is the most accurate.
    Verification: Other options relate to molecular weight or polymeric nature, which are not the primary reasons for lipids being in the insoluble fraction.
 ## OPTION ANALYSIS
[A] :x:  While some lipids have larger molecular weights, it's not the primary reason for their presence in the insoluble fraction. Many small lipids also end up in the insoluble fraction.
[B] :x: Lipids are not typically considered true polymers like proteins or nucleic acids. This is not the reason for their insolubility.
[C] :x: Lipids, although having a lower molecular weight than many biomolecules, are insoluble because of their hydrophobic nature and membrane structure, not just their low molecular weight.
[D] ✓: This is the correct explanation. The disruption of cell membranes during grinding causes lipids to form insoluble vesicles, leading to their presence in the acid-insoluble fraction.
 ## LEARNING AIDS
**Common Mistakes**:
1.  Thinking solubility is only based on molecular weight: Many students might incorrectly assume that low molecular weight automatically means solubility and high molecular weight means insolubility. This is not always the case.
2.  Ignoring the membrane context: It's easy to overlook the fact that lipids exist mainly as part of the biomembrane and not as free molecules in the cell. This membrane structure directly affects their solubility.
**Quick Tips**:
1.  Think about the hydrophobic nature of lipids and how they aggregate in aqueous solutions.
2.  Visualize the breaking of the cell membrane into smaller fragments that are insoluble.

B VENKAT · Answer

It has very high molecular weight

B VENKAT · Answer

It is polymer

B VENKAT · Answer

It has low molecular weight

B VENKAT · Answer

The correct Option is "On grinding, the biomembranes are broken into pieces and form insoluble vesicles"

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