The 'histone code' hypothesis proposes that specific combinations of histone modifications influence gene expression. If a researcher discovered a novel histone modification, which experimental approach would be LEAST informative for initially investigating its potential role in gene regulation?
Analyzing the genome-wide distribution of the modification using ChIP-seq.
Correlating the presence of the modification with gene expression levels.
Assessing the binding of specific regulatory proteins to the modified histone.
Determining the crystal structure of the modified histone.
Related Questions
A chromosome with its centromere located precisely in the middle, dividing it into two arms of equal length, is classified as:
Telocentric
Metacentric
Acrocentric
Submetacentric
If the centromere divides a chromosome into two equal halves, what type of chromosome is it?
Metacentric
Submetacentric
Acrocentric
Telocentric
In which type of chromosome does the centromere lie exactly at the midpoint?
Acrocentric
Metacentric
Submetacentric
Telocentric
Certain histone modifications are associated with actively transcribed genes. Which of the following combinations is MOST likely to be found in the nucleosomes of such genes?
Methylation of H3K9 and H3K27; Deacetylation of H3 and H4
Phosphorylation of H2AX; Trimethylation of H3K9
Acetylation of H3 and H4; Trimethylation of H3K4
Ubiquitination of H2A; Trimethylation of H3K27
Which of the following is NOT a characteristic of a metacentric chromosome?
Two arms of equal length
Centromere located in the middle
Centromere located near one end
Forms a V-shape during cell division
