The 'histone code' hypothesis proposes that specific combinations of histone modifications influence gene expression. If a researcher discovered a novel histone modification, which experimental approach would be LEAST informative for initially investigating its potential role in gene regulation?
Analyzing the genome-wide distribution of the modification using ChIP-seq.
Correlating the presence of the modification with gene expression levels.
Assessing the binding of specific regulatory proteins to the modified histone.
Determining the crystal structure of the modified histone.
Related Questions
The 'histone code' hypothesis proposes that specific combinations of histone modifications influence gene expression. If a researcher discovered a novel histone modification, which experimental approach would be LEAST informative for initially investigating its potential role in gene regulation?
Analyzing the genome-wide distribution of the modification using ChIP-seq.
Correlating the presence of the modification with gene expression levels.
Assessing the binding of specific regulatory proteins to the modified histone.
Determining the crystal structure of the modified histone.
In contrast to the core histones, histone H1's primary function relates to:
Forming the nucleosome core
DNA replication
Higher-order chromatin folding
Transcription initiation
The positive charge of histone proteins facilitates their interaction with:
Positively charged RNA
Neutral lipids
Negatively charged DNA
Other histone proteins
When the Centrometre is situated in the middle of two equal arms of chromosomes, the chromosome is referred as:
Sub-metacentric
Acrocentric
Metacentric
Telocentric
Histone H1 plays a crucial role in the structure of chromatin. Which of the following statements regarding its interaction and function is INCORRECT?
H1 binds to the linker DNA between nucleosomes.
H1 helps to compact chromatin structure.
H1 interacts with the core histones within the nucleosome octamer.
H1 stabilizes the interaction of DNA with the nucleosome.
Which of the following correctly describes the arms of a submetacentric chromosome?
Shorter arm is 'p' and longer arm is 'q'
Both arms are equal in length
Shorter arm is 'q' and longer arm is 'p'
Shorter arm is 'm' and longer arm is 'l'
The shorter and longer arms of a submetacentric chromosome are referred to as
S – arm and l – arm respectively
p – arm and q – arm respectively
q – arm and p – arm respectively
m – arm and n – arm respectively
A chromosome with its centromere located precisely in the middle, dividing it into two arms of equal length, is classified as:
Telocentric
Metacentric
Acrocentric
Submetacentric
In a submetacentric chromosome, the shorter arm is designated as:
p
q
m
s
Which of the following processes is facilitated by the binding of histone H1 to a nucleosome?
DNA unwinding
Chromatin condensation
RNA splicing
Protein synthesis
