In an experiment, a researcher selectively removes histone H4 from chromatin. Which of the following is the MOST likely immediate consequence?
Increased condensation of the chromatin fiber.
Enhanced binding of RNA polymerase to promoter regions.
Specific activation of a subset of genes.
Significant destabilization of the nucleosome core and loss of DNA wrapping.
Related Questions
In which type of chromosome are Balbiani rings observed?
Polytene
Metacentric
Submetacentric
Acrocentric
Approximately how many base pairs of DNA are wrapped around a single nucleosome core?
200
50
146
250
Which of these processes is directly influenced by the level of chromatin compaction?
DNA replication
RNA processing
Gene expression
Protein translation
Balbiani rings are prominent structures found in:
Polytene chromosomes
Lampbrush chromosomes
Meiotic chromosomes
Mitotic chromosomes
The 'histone code' hypothesis proposes that specific combinations of histone modifications influence gene expression. If a researcher discovered a novel histone modification, which experimental approach would be LEAST informative for initially investigating its potential role in gene regulation?
Analyzing the genome-wide distribution of the modification using ChIP-seq.
Correlating the presence of the modification with gene expression levels.
Assessing the binding of specific regulatory proteins to the modified histone.
Determining the crystal structure of the modified histone.
Certain histone modifications are associated with actively transcribed genes. Which of the following combinations is MOST likely to be found in the nucleosomes of such genes?
Methylation of H3K9 and H3K27; Deacetylation of H3 and H4
Phosphorylation of H2AX; Trimethylation of H3K9
Acetylation of H3 and H4; Trimethylation of H3K4
Ubiquitination of H2A; Trimethylation of H3K27
Spindle fibres attach on to:
Telomere of the chromosome
Kinetochore of the chromosome
Centromere of the chromosome
Kinetosome of the chromosome
In an experiment, a researcher selectively removes histone H4 from chromatin. Which of the following is the MOST likely immediate consequence?
Increased condensation of the chromatin fiber.
Enhanced binding of RNA polymerase to promoter regions.
Specific activation of a subset of genes.
Significant destabilization of the nucleosome core and loss of DNA wrapping.
The large puffs on polytene chromosomes, known as Balbiani rings, are primarily involved in:
RNA synthesis
DNA replication
Protein degradation
Chromosome condensation
A chromosome with its centromere located precisely in the middle, dividing it into two arms of equal length, is classified as:
Telocentric
Metacentric
Acrocentric
Submetacentric
