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Histone H1 plays a crucial role in the structure of chromatin. Which of the following statements regarding its interaction and function is INCORRECT?
H1 binds to the linker DNA between nucleosomes.
H1 helps to compact chromatin structure.
H1 interacts with the core histones within the nucleosome octamer.
H1 stabilizes the interaction of DNA with the nucleosome.
A researcher isolates chromatin fibers and treats them with a nuclease that specifically cleaves linker DNA. Following this treatment, what would be the approximate size distribution of the DNA fragments observed?
Approximately 200 bp
Approximately 1000 bp
Approximately 50 bp
A wide range of sizes from 200 bp to several thousand bp
In an experiment, a researcher selectively removes histone H4 from chromatin. Which of the following is the MOST likely immediate consequence?
Increased condensation of the chromatin fiber.
Enhanced binding of RNA polymerase to promoter regions.
Specific activation of a subset of genes.
Significant destabilization of the nucleosome core and loss of DNA wrapping.
Approximately how many base pairs of DNA are wrapped around a single nucleosome core?
200
50
146
250
The presence of histone H1 in association with a nucleosome suggests:
Further compaction of chromatin structure
Transcription activation
DNA replication initiation
Nucleosome disassembly
Which of the following processes is facilitated by the binding of histone H1 to a nucleosome?
DNA unwinding
Chromatin condensation
RNA splicing
Protein synthesis
In contrast to the core histones, histone H1's primary function relates to:
Forming the nucleosome core
DNA replication
Higher-order chromatin folding
Transcription initiation
Which of the following statements regarding chromatin organization are correct?
(a) Euchromatin is loosely packed and transcriptionally active.
(b) Heterochromatin is densely packed and transcriptionally inactive.
(c) The nucleosome core particle consists of a histone octamer wrapped by negatively charged DNA.
(d) Histones are rich in basic amino acids like lysine and arginine.
(e) A typical nucleosome contains approximately 200 bp of DNA helix.
a, b, c
a, c, d
b, c, e
a, b, c, d, e
Solenoid is a structure of
Nucleosomal organisation with 10nm thickness
Condensed chromatin fibre with 30nm diameter
Highly condensed form of chromatid with 300 nm thickness
Well organised chromatid with 700 nm thickness
