The Question is from neet-botany cell-biology , and it was created by the author K SURESH KUMAR

Question

Mannose-6-phosphate receptors are crucial for targeting proteins to which cellular compartment?

K SURESH KUMAR · Accepted Answer

## CORE INFORMATION
✓ **Answer**: C
## CONCEPT FRAMEWORK
	**Primary Concept**: Protein sorting and trafficking within the cell.
	**Related Topics**: Lysosomal function, Golgi apparatus, receptor-mediated endocytosis.
	**Prerequisites**: Basic understanding of cellular organelles and protein modification.
## SOLUTION PATHWAY
**Given Information**:
	The question asks about the role of mannose-6-phosphate receptors.
**Method & Steps**:
	1. **Identify the function of mannose-6-phosphate receptors:** Mannose-6-phosphate receptors are transmembrane proteins located in the trans-Golgi network (TGN). Their primary function is to bind to proteins that have been tagged with mannose-6-phosphate (M6P) groups. This tagging acts as a signal that directs the protein to lysosomes.
	2. **Determine the destination of M6P-tagged proteins:**  Proteins bearing the M6P tag bind to the mannose-6-phosphate receptors in the TGN.  The receptor-ligand complex is then transported via vesicles to the lysosomes. Once in the lysosomal environment, the low pH causes the release of the protein from the receptor, allowing the receptor to be recycled back to the TGN.
	3. **Identify the correct cellular compartment:** Based on the above, the cellular compartment targeted by proteins bound to mannose-6-phosphate receptors is the lysosome.
		Result: Lysosomes
		Verification: This aligns with the established understanding of lysosomal protein targeting mechanisms.
## OPTION ANALYSIS
A :x: Mitochondria are involved in cellular respiration and ATP production.  They do not utilize mannose-6-phosphate receptors for protein targeting.
B :x: The nucleus houses the cell's genetic material.  Nuclear protein import uses different mechanisms than M6P-receptor mediated transport.
C ✓: Lysosomes are involved in intracellular degradation and utilize mannose-6-phosphate receptors to receive hydrolytic enzymes.
D :x: Peroxisomes are involved in various metabolic processes, including fatty acid oxidation. They don't use mannose-6-phosphate receptors for protein targeting.
## LEARNING AIDS
	**Common Mistakes**:
		1. Confusing mannose-6-phosphate receptors with other receptor types involved in different cellular processes:  Remembering that M6P receptors are specific to lysosomal targeting is crucial.
		2.  Misunderstanding the role of the Golgi apparatus: The Golgi apparatus is crucial in modifying and sorting proteins, including those destined for lysosomes via M6P receptors.
	**Quick Tips**:
		1.  Associate mannose-6-phosphate with lysosomes directly.
		2.  Visualize the pathway: Golgi → M6P receptor binding → Vesicle transport → Lysosome.

K SURESH KUMAR · Answer

Mitochondria

K SURESH KUMAR · Answer

Nucleus

K SURESH KUMAR · Answer

The correct Option is "Lysosomes"

K SURESH KUMAR · Answer

Peroxisomes

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