The Question is from neet-chemistry principles-related-to-practical-chemistry drugs-and-their-classification, and it was created by the author P SRAVAN KUMAR

Question

Which of the following statements regarding the mechanism of action of benzodiazepines is INCORRECT?

P SRAVAN KUMAR · Accepted Answer

## CORE INFORMATION
✓ **Answer**: C
## CONCEPT FRAMEWORK
 **Primary Concept**: Mechanism of action of benzodiazepines
 **Related Topics**: GABAergic neurotransmission, GABA$_A$ receptor, chloride channels, dopamine neurotransmission, competitive antagonism
 **Prerequisites**: Basic understanding of neurotransmission and receptor pharmacology.
## SOLUTION PATHWAY
**Given Information**:
  Four statements regarding the mechanism of action of benzodiazepines.
  The task is to identify the incorrect statement.
**Method & Steps**:
 1. Analyze each statement individually to determine its accuracy.
  Reasoning: Evaluate each statement against the known mechanism of action of benzodiazepines.
  Formula/Rule: N/A
 2. Identify the statement that is inconsistent with the established mechanism of action.
  Working:  Benzodiazepines are allosteric modulators of the GABA$_A$ receptor. They bind to a specific site on the receptor, increasing the frequency of chloride channel opening, thereby enhancing the inhibitory effect of GABA. This effect is reversed by flumazenil, a competitive antagonist.  They do *not* act as dopamine agonists.
  Key Point:  Understanding the difference between allosteric modulation and direct agonism is crucial.
 3. Select the incorrect statement as the answer.
  Result: Statement C is incorrect.
  Verification:  The other statements accurately describe aspects of benzodiazepine mechanism of action. 
 ## OPTION ANALYSIS
A ✓: Correct. Benzodiazepines enhance GABA's effect by increasing the frequency of chloride channel opening.
B ✓: Correct. Benzodiazepines bind to a specific site on the GABA$_A$ receptor.
C :x: Incorrect. Benzodiazepines do not act as dopamine agonists. They primarily affect GABAergic neurotransmission.
D ✓: Correct. Flumazenil, a competitive antagonist, can reverse the effects of benzodiazepines.
 ## LEARNING AIDS
 **Common Mistakes**:
  1.Confusing benzodiazepines' mechanism with other drug classes (e.g., dopamine agonists):  Focus on the GABA$_A$ receptor and chloride channel modulation.
  2.Misunderstanding allosteric modulation: Recognize that benzodiazepines don't directly activate the receptor but enhance the effect of the endogenous ligand (GABA).
 **Quick Tips**:
  1.Remember the key players: GABA, GABA$_A$ receptor, chloride channels, and flumazenil.
  2.Visualize the benzodiazepine binding to the GABA$_A$ receptor, increasing chloride influx and hyperpolarization.

P SRAVAN KUMAR · Answer

They enhance the effect of GABA by increasing the frequency of chloride channel opening.

P SRAVAN KUMAR · Answer

They bind to a specific site on the GABA$_A$ receptor complex.

P SRAVAN KUMAR · Answer

The correct Option is "They act as dopamine agonists, enhancing dopaminergic neurotransmission."

P SRAVAN KUMAR · Answer

Their effects can be reversed by flumazenil, a competitive antagonist.

NEET Chemistry Chemistry In Everyday Life Drugs And Their Classification MCQs

Select Topic

Question Tags

Question Tags

Question Tags

Question Tags

Question Tags

Question Tags

Question Tags

Question Tags

Question Tags

Question Tags

NEET Subjects

Our Bots

Company