The Question is from neet-zoology breathing-and-exchange-of-gases , and it was created by the author A SUBRAMANYAM

Question

During strenuous exercise, a significant increase in the concentration of 2,3-bisphosphoglycerate (2,3-BPG) in erythrocytes is observed. This increase PRIMARILY facilitates which of the following?

A SUBRAMANYAM · Accepted Answer

## CORE INFORMATION
✓ **Answer**: B
## CONCEPT FRAMEWORK
 **Primary Concept**: Oxygen-hemoglobin dissociation curve and the effect of 2,3-BPG.
 **Related Topics**: Erythrocytes, gas transport in blood, Bohr effect.
 **Prerequisites**: Understanding of hemoglobin structure and function, oxygen binding affinity.
## SOLUTION PATHWAY
**Given Information**:
  Increased concentration of 2,3-BPG in erythrocytes during strenuous exercise.
  
**Method & Steps**:
 1. Understand the role of 2,3-BPG.
  Reasoning: 2,3-BPG is an allosteric regulator of hemoglobin.  It binds to the deoxyhemoglobin form, stabilizing it and reducing its affinity for oxygen.
  Formula/Rule: None directly applicable, but understanding the relationship between 2,3-BPG and oxygen affinity is key.
 2. Consider the physiological context of strenuous exercise.
  Working: During exercise, tissues require more oxygen.  Increased 2,3-BPG helps to facilitate the release of oxygen from hemoglobin in the tissues.
  Key Point: The shift in the oxygen-hemoglobin dissociation curve to the right, caused by increased 2,3-BPG, indicates a lower oxygen affinity and enhanced oxygen unloading in the tissues.
 3. Analyze the options.
  Result: Option B, enhanced oxygen unloading in tissues, is the primary effect of increased 2,3-BPG.
  Verification: The other options are incorrect because increased 2,3-BPG does not directly increase oxygen binding in the lungs, increase carbon dioxide transport, or reduce fetal hemoglobin's oxygen affinity (fetal hemoglobin has a lower affinity for 2,3-BPG).
 ## OPTION ANALYSIS
A :x: Increased oxygen binding in the lungs: 2,3-BPG decreases oxygen affinity, thus hindering oxygen binding in the lungs.
B ✓: Enhanced oxygen unloading in tissues: This is the primary effect of increased 2,3-BPG.  It facilitates the release of oxygen where it is needed most.
C :x: Increased carbon dioxide transport in blood: While 2,3-BPG indirectly influences CO2 transport (by affecting oxygen levels which influences CO2 binding), it's not the primary effect.
D :x: Reduced oxygen affinity of fetal hemoglobin: Fetal hemoglobin has a lower affinity for 2,3-BPG than adult hemoglobin, making it better at binding oxygen.
 ## LEARNING AIDS
 **Common Mistakes**:
  1.Confusing the effect of 2,3-BPG on oxygen binding and unloading: Remember it decreases oxygen affinity, leading to enhanced unloading.
  2.Ignoring the physiological context of exercise: Increased oxygen demand in tissues is the reason for the 2,3-BPG increase.
 **Quick Tips**:
  1.Remember the rightward shift of the oxygen-hemoglobin dissociation curve with increased 2,3-BPG.
  2.Associate 2,3-BPG with enhanced oxygen delivery to tissues during exercise.

A SUBRAMANYAM · Answer

Increased oxygen binding in the lungs

A SUBRAMANYAM · Answer

The correct Option is "Enhanced oxygen unloading in tissues"

A SUBRAMANYAM · Answer

Increased carbon dioxide transport in blood

A SUBRAMANYAM · Answer

Reduced oxygen affinity of fetal hemoglobin

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