A patient presents with a tumor that shows evidence of loss of heterozygosity (LOH) at a specific locus. Which of the following is the MOST likely explanation for this observation and its significance in cancer development?
Duplication of the mutated allele of an oncogene; Inhibits tumor formation.
Deletion of the normal allele of a tumor suppressor gene; Promotes tumor formation.
Translocation involving a proto-oncogene; Has no effect on tumor formation.
Inversion within a tumor suppressor gene; Suppresses tumor formation.
Related Questions
Which of these is a proto-oncogene?
p53
Rb
ras
BRCA1
Retinoblastoma, a childhood cancer of the eye, is primarily caused by a mutation in which gene, and how does this mutation contribute to cancer development?
p53 gene; Gain of function mutation promotes DNA repair.
RB gene; Loss of function mutation leads to uncontrolled cell cycle progression.
BRCA1 gene; Loss of function mutation impairs DNA damage repair.
RAS gene; Gain of function mutation inhibits apoptosis.
Alteration of which genes leads to cancer?
Cell proliferation gene(proto-oncogenes)
Tumour suppressor gene
Tumour virus gene
All of the above
A patient presents with a tumor that shows evidence of loss of heterozygosity (LOH) at a specific locus. Which of the following is the MOST likely explanation for this observation and its significance in cancer development?
Duplication of the mutated allele of an oncogene; Inhibits tumor formation.
Deletion of the normal allele of a tumor suppressor gene; Promotes tumor formation.
Translocation involving a proto-oncogene; Has no effect on tumor formation.
Inversion within a tumor suppressor gene; Suppresses tumor formation.
The Philadelphia chromosome is found in the patients suffering from
Albinism
Hepatitis
Insomnia
Leukaemia
The genes concerned with the production of cancer are called
Cancer genes
Carcinogenes
Carcinomas
Oncogenes
