A patient presents with a tumor that shows evidence of loss of heterozygosity (LOH) at a specific locus. Which of the following is the MOST likely explanation for this observation and its significance in cancer development?
Duplication of the mutated allele of an oncogene; Inhibits tumor formation.
Deletion of the normal allele of a tumor suppressor gene; Promotes tumor formation.
Translocation involving a proto-oncogene; Has no effect on tumor formation.
Inversion within a tumor suppressor gene; Suppresses tumor formation.
Related Questions
Cancerous cells spread through
Lymph
Blood
Secondary growths of malignant tumour
All of the above
The process by which cancer cells spread to distant sites in the body is called:
Apoptosis
Metastasis
Differentiation
Transformation
Malignant tumours are
I. mass of neoplastic cells
II. cells that grow very rapidly and damaging the surrounding normal tissue
III. cells that show the property of metastisis
Which of the statements given above are correct?
I and II
I and III
II and III
All of these
The genes concerned with the production of cancer are called
Cancer genes
Carcinogenes
Carcinomas
Oncogenes
Which is not cancer?
Leukaemia
Trachoma
Carcinoma
Sarcoma
X-rays are used in
Medical imaging
Security screening
Industrial inspection
All of the above
Lung cancer is caused by
Tabacco smoke
X-rays
UR rays
Vehicle smoke
Alteration of which genes leads to cancer?
Cell proliferation gene(proto-oncogenes)
Tumour suppressor gene
Tumour virus gene
All of the above
Which one of the following is not the property of cancerous cells?
They do not require extracellular growth factors
They do not remain confined in the area of formation
They show contact inhibition
They divide in an uncontrolled manner
Contact inhibition is lost in cancer cells. This means:
Cancer cells stop dividing when they contact other cells.
Cancer cells continue to divide even when they are crowded.
Cancer cells require contact with other cells to divide.
Cancer cells lose their ability to adhere to other cells.
