1.

    A patient presents with a tumor that shows evidence of loss of heterozygosity (LOH) at a specific locus. Which of the following is the MOST likely explanation for this observation and its significance in cancer development?

    A

    Duplication of the mutated allele of an oncogene; Inhibits tumor formation.

    B

    Deletion of the normal allele of a tumor suppressor gene; Promotes tumor formation.

    C

    Translocation involving a proto-oncogene; Has no effect on tumor formation.

    D

    Inversion within a tumor suppressor gene; Suppresses tumor formation.

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