The Question is from neet-botany biomolecules-biology , and it was created by the author K SURESH KUMAR

Question

A rare genetic disorder affects lipid metabolism by impairing the synthesis of plasmalogens.  Which membrane component would be MOST directly affected?

K SURESH KUMAR · Accepted Answer

## CORE INFORMATION
✓ **Answer**: C
## CONCEPT FRAMEWORK
 **Primary Concept**: Membrane structure and composition
 **Related Topics**: Lipid metabolism, genetic disorders, myelin sheath function
 **Prerequisites**: Understanding of phospholipids, plasmalogens, and the composition of different cellular membranes.
## SOLUTION PATHWAY
**Given Information**:
A rare genetic disorder impairs plasmalogen synthesis.
**Method & Steps**:
1. Identify the role of plasmalogens.
  Reasoning: Plasmalogens are a type of phospholipid found in cell membranes, particularly enriched in myelin sheaths.
  Formula/Rule:  None explicitly required.
2. Determine which membrane is most affected by plasmalogen deficiency.
  Working: Since plasmalogens are crucial components of myelin, a deficiency in their synthesis would most directly impact the myelin sheath's structure and function.
  Key Point: Myelin sheaths are crucial for the proper functioning of the nervous system, and their integrity depends heavily on the composition of their lipid bilayer, including plasmalogens.
3. Select the correct option.
  Result: The myelin sheath is the membrane component most directly affected by impaired plasmalogen synthesis.
  Verification: The other options, mitochondrial inner membrane, nuclear envelope, and lysosomal membrane, while containing phospholipids, do not have the same high concentration of plasmalogens as the myelin sheath.
 ## OPTION ANALYSIS
A :x: Mitochondrial inner membranes contain phospholipids, but plasmalogens are not their primary component.
B :x: The nuclear envelope is composed of a lipid bilayer, but plasmalogens are not its major constituent.
C ✓: Myelin sheaths are rich in plasmalogens; their deficiency directly affects myelin structure and function.
D :x: Lysosomal membranes contain phospholipids, but plasmalogens are not their primary component.
 ## LEARNING AIDS
 **Common Mistakes**:
  1.Confusing plasmalogens with other phospholipids:  Remembering the unique characteristics of plasmalogens and their specific location is crucial.
  2.Not considering the relative abundance of plasmalogens in different membranes:  Myelin's high plasmalogen content is key to answering the question correctly.
 **Quick Tips**:
  1.Focus on the specific lipid mentioned in the question (plasmalogens).
  2.Recall the major components and functions of different cell membranes.

K SURESH KUMAR · Answer

Mitochondrial inner membrane

K SURESH KUMAR · Answer

Nuclear envelope

K SURESH KUMAR · Answer

The correct Option is "Myelin Sheath"

K SURESH KUMAR · Answer

Lysosomal membrane

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