The most likely reason for the development of resistance against pesticides in insect damaging a crop is
The pesticide causes mutations in the insects that make them resistant.
Some insects have genes that make them resistant to the pesticide, and these genes are passed on to their offspring.
The insects learn to avoid areas where the pesticide has been applied.
The pesticide strengthens the insects' immune systems, making them resistant.
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A plant species which has been exploited for the production of hirudin is
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Oryza sativa