The 'histone code' hypothesis proposes that specific combinations of histone modifications influence gene expression. If a researcher discovered a novel histone modification, which experimental approach would be LEAST informative for initially investigating its potential role in gene regulation?
Analyzing the genome-wide distribution of the modification using ChIP-seq.
Correlating the presence of the modification with gene expression levels.
Assessing the binding of specific regulatory proteins to the modified histone.
Determining the crystal structure of the modified histone.
Related Questions
The association of histone H1 with a nucleosome indicates:
The DNA double helix is exposed
Transcription is occurring
DNA replication is occurring
The DNA is condensed into a Chromatin Fibre
The presence of histone H1 in association with a nucleosome suggests:
Further compaction of chromatin structure
Transcription activation
DNA replication initiation
Nucleosome disassembly
In eukaryotes, the fundamental repeating unit of chromatin is called a:
Solenoid
Chromatid
Centromere
Nucleosome
In contrast to the core histones, histone H1's primary function relates to:
Forming the nucleosome core
DNA replication
Higher-order chromatin folding
Transcription initiation
Which histone protein is NOT part of the nucleosome core octamer?
H2A
H2B
H3
H1
Approximately how many base pairs of DNA are wrapped around a histone octamer in a nucleosome?
20
146
200
1000
Which of the following processes is facilitated by the binding of histone H1 to a nucleosome?
DNA unwinding
Chromatin condensation
RNA splicing
Protein synthesis
Which of the following is the basic repeating unit of chromatin?
Gene
Chromosome
Centromere
Nucleosome
In an experiment, a researcher selectively removes histone H4 from chromatin. Which of the following is the MOST likely immediate consequence?
Increased condensation of the chromatin fiber.
Enhanced binding of RNA polymerase to promoter regions.
Specific activation of a subset of genes.
Significant destabilization of the nucleosome core and loss of DNA wrapping.
The structure formed by DNA wrapped around histone proteins is called:
Chromosome
Chromatid
Chromatin
Centromere
