The Question is from neet-botany , and it was created by the author B VENKAT

Question

Anaphase promoting complex (APC) is a protein degradation machinery necessary for proper mitosis of animal cells. If APC is defective in a human cell, which of the following is expected to occur?

B VENKAT · Accepted Answer

## CORE INFORMATION
✓ **Answer**: D
## CONCEPT FRAMEWORK
	**Primary Concept**: Function of the Anaphase Promoting Complex (APC) in mitosis.
	**Related Topics**: Cell Cycle, Mitosis stages, Protein degradation, Chromosome dynamics.
	**Prerequisites**: Basic understanding of mitosis and the role of APC in cell division.
## SOLUTION PATHWAY
**Given Information**:
	* APC is a protein degradation machinery.
	* APC is necessary for proper mitosis.
	* The question asks what happens when APC is defective.
**Method & Steps**:
	1.  Understand the function of APC: The Anaphase Promoting Complex (APC) is a ubiquitin ligase that targets specific proteins for degradation. This degradation is essential for the transition from metaphase to anaphase in mitosis.
		Reasoning: APC activation leads to the degradation of proteins holding sister chromatids together, allowing them to separate.
		Formula/Rule: N/A
	2.  Identify the consequence of APC defect: If APC is defective, it will be unable to degrade the proteins that hold sister chromatids together.  This means the sister chromatids will not separate.
		Working: Defective APC -> No degradation of cohesion proteins -> Sister chromatids remain attached.
		Key Point: Chromosome segregation is dependent on the proper function of APC.
	3.  Relate to answer choices: Chromosomes not segregating corresponds to option D.
		Result: Option D is the correct answer.
		Verification: Other options are not directly linked to the primary function of APC.
 ## OPTION ANALYSIS
[A] :x: Recombination occurs during meiosis, not mitosis.  APC is not involved in recombination.
[B] :x: Chromosome condensation occurs earlier in mitosis. APC is not directly involved in condensation.
[C] :x: Chromosome fragmentation is not a direct consequence of APC defects.  Defective APC causes segregation issues.
[D] ✓: If APC is defective, the sister chromatids will not separate properly and therefore chromosomes will not segregate.
 ## LEARNING AIDS
	**Common Mistakes**:
		1. Confusing APC function with other mitotic processes: APC is specifically involved in sister chromatid separation, not other events like condensation or recombination.
		2. Not understanding the direct link between APC and chromatid separation: Remember that APC activation leads to the degradation of proteins holding sister chromatids together.
	**Quick Tips**:
		1. Think of APC as the 'switch' that allows the transition from metaphase to anaphase.
		2. Memorize that APC is a ubiquitin ligase and its function is related to protein degradation.

B VENKAT · Answer

Recombination of chromosome arms will occur

B VENKAT · Answer

Chromosomes will not condense

B VENKAT · Answer

Chromosomes will be fragmented

B VENKAT · Answer

The correct Option is "Chromosomes will not segregate"

NEET Botany MCQs

Select Chapter

Question Tags

Question Tags

Question Tags

Question Tags

Question Tags

Question Tags

Question Tags

Question Tags

Question Tags

Question Tags

NEET Subjects

Our Bots

Company