The Question is from neet-zoology chemical-coordincation-and-integration testis, and it was created by the author Mr. BALACHANDRA.N

Question

A mutation affecting the function of the androgen receptor in the testis would MOST directly impair which of the following processes?

Mr. BALACHANDRA.N · Accepted Answer

## CORE INFORMATION
✓ **Answer**: [Option B]
## CONCEPT FRAMEWORK
	**Primary Concept**: Androgen receptor function and its role in reproductive physiology
	**Related Topics**: Hormonal regulation, spermatogenesis, testicular function
	**Prerequisites**: Basic understanding of the endocrine system, specifically the role of androgens in male reproductive health
## SOLUTION PATHWAY
**Given Information**:
		- Mutation affecting the androgen receptor function
		- Processes involved in testicular function
**Method & Steps**:
	1.	Identify the role of the androgen receptor in the testis.
		Reasoning: The androgen receptor is crucial for mediating the effects of testosterone, which is essential for spermatogenesis.
		Formula/Rule: The biological action of testosterone is mediated through androgen receptors on target tissues.
	2.	Assess the options provided in the question.
		Working: Evaluate how each option relates to the function of androgens in the testis.
		Key Point: Spermatogenesis is directly influenced by testosterone action via androgen receptors.
	3.	Conclusion based on the assessed options.
		Result: Spermatogenesis would be directly impaired by a mutation affecting the androgen receptor, as it relies on proper androgen signaling.
		Verification: Other processes such as testosterone synthesis and Mullerian duct regression are not directly dependent on the androgen receptor's function in the testis.
## OPTION ANALYSIS
[A] :x: Testosterone synthesis is primarily regulated by Leydig cells and not directly by the androgen receptor in the testis.
[B] ✓: Spermatogenesis is directly affected as it relies on the androgen receptor for the action of testosterone, essential for the development of sperm.
[C] :x: Mullerian duct regression is mainly influenced by anti-Mullerian hormone (AMH) rather than the androgen receptor's function.
[D] :x: Descent of the testes is regulated by hormonal signals, but not directly through the androgen receptor function in the testis, making it less directly affected by this mutation.
## LEARNING AIDS
	**Common Mistakes**:
		1. Confusing the role of testosterone synthesis with the action of androgens: Remember that synthesis occurs in Leydig cells, while action requires receptors.
		2. Overlooking the specific processes influenced by androgens: Focus on spermatogenesis when considering androgen receptor function.
	**Quick Tips**:
		1. Link the androgen receptor directly to spermatogenesis when studying male reproductive physiology.
		2. Remember that the effects of androgens are mediated through receptors, making the receptors critical for sperm development.

Mr. BALACHANDRA.N · Answer

Testosterone synthesis

Mr. BALACHANDRA.N · Answer

The correct Option is "Spermatogenesis"

Mr. BALACHANDRA.N · Answer

Mullerian duct regression

Mr. BALACHANDRA.N · Answer

Descent of the testes

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