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NEET Questions / Zoology / Chemical Coordination and Integration / Testis
Which specific cell type within the testis is primarily responsible for the synthesis and secretion of inhibin, a hormone that regulates FSH secretion?
Leydig cells
Sertoli cells
Spermatogonia
Myoid cells
A mutation affecting the function of the androgen receptor in the testis would MOST directly impair which of the following processes?
Testosterone synthesis
Spermatogenesis
Mullerian duct regression
Descent of the testes
During the development of the male reproductive system, the testis-determining factor (TDF) initiates the differentiation of the indifferent gonad into a testis. Which of the following accurately describes the subsequent cascade of events related to testicular descent?
Sertoli cells produce testosterone, stimulating Wolffian duct development, while Leydig cells produce AMH, causing Müllerian duct regression. Testicular descent is independent of hormonal influence.
Leydig cells produce both testosterone and AMH, leading to Wolffian duct development and Müllerian duct regression, respectively. INSL3 inhibits testicular descent until puberty.
Sertoli cells produce AMH, leading to Müllerian duct regression, followed by testosterone production by Leydig cells, promoting Wolffian duct development. INSL3 mediates transabdominal testicular descent, and androgens contribute to the inguinoscrotal phase.
Testosterone production precedes AMH production, and both are secreted by Leydig cells. The gubernaculum pulls the testes into the abdomen, and INSL3 initiates their descent into the scrotum.
A rare genetic disorder affects the blood-testis barrier, specifically compromising the tight junctions between Sertoli cells. Which of the following is the MOST likely consequence of this compromised barrier?
Increased testosterone production
Enhanced spermatogenesis
Autoimmune response against developing sperm
Premature release of immature sperm
Cryptorchidism is a condition characterized by the failure of one or both testes to descend into the scrotum. Which of the following hormonal imbalances is MOST directly associated with an increased risk of cryptorchidism?
Excess testosterone production
Insufficient INSL3 production
Elevated AMH levels
Reduced FSH secretion
The primary function of the seminiferous tubules in the testis is:
Spermatogenesis
Secretion of testosterone
Storage of sperm
Maturation of sperm
Which cells in the testis are responsible for the production of testosterone?
Sertoli cells
Leydig cells
Spermatogonia
Spermatids
What is the function of Sertoli cells in the testis?
Produce testosterone
Provide nourishment to developing sperm
Store sperm
Transport sperm