The Question is from neet-zoology , and it was created by the author BALASOURY

Question

A researcher is developing a DNA vaccine against a viral infection. Which of the following is NOT a crucial consideration for the effectiveness of this vaccine?

BALASOURY · Accepted Answer

## CORE INFORMATION
✓ **Answer**: D
## CONCEPT FRAMEWORK
 **Primary Concept**: DNA vaccine mechanism and effectiveness
 **Related Topics**: Immunology, virology, vaccine development
 **Prerequisites**: Understanding of DNA replication, transcription, translation, immune response (humoral and cell-mediated immunity), antigen presentation.
## SOLUTION PATHWAY
**Given Information**:
  The question asks about crucial considerations for the effectiveness of a DNA vaccine.
  Options describe different aspects of DNA vaccine function.
**Method & Steps**:
 1. Analyze each option to determine its importance in DNA vaccine efficacy.
  Reasoning: A DNA vaccine works by introducing a DNA plasmid encoding viral antigens into host cells.  The host cells then express these antigens, triggering an immune response.
 2. Identify the option that is NOT essential for a successful DNA vaccine.
  Working: Let's examine each option:
  A. Efficient delivery is crucial; without it, the DNA won't reach the cells.
  B. Antigen expression is essential; without it, there's no immune response.
  C. Activation of both humoral and cell-mediated immunity is crucial for a robust and long-lasting response.
  D. While viral-like particles (VLPs) can enhance antigen presentation, they are not strictly necessary for a DNA vaccine to work. The DNA itself can induce an immune response.
 3. Conclude which option is NOT crucial.
  Result: The inclusion of viral-like particles is not a crucial consideration for the effectiveness of a DNA vaccine, although it can improve it.
  Verification: A DNA vaccine's core mechanism relies on successful DNA delivery, antigen expression, and immune response activation. VLPs are an enhancement, not a requirement.
 ## OPTION ANALYSIS
A ✓: Efficient delivery is absolutely necessary for the DNA plasmid to reach the host cells and initiate the process.  Without this, the vaccine will not work.
B :x: Expression of viral antigens is fundamental.  The host cells must produce the antigens to trigger an immune response.
C :x:  Both humoral (antibody-mediated) and cell-mediated immunity are needed for a complete and effective immune response to the viral infection.
D :x: While VLPs can enhance the immune response by improving antigen presentation, they are not essential for the vaccine's function. The expressed viral antigens themselves can effectively trigger an immune response. 
 ## LEARNING AIDS
 **Common Mistakes**:
  1.Confusing necessary components with beneficial additions: VLPs improve the vaccine but are not strictly necessary.
  2.Overlooking the importance of immune response activation: Both humoral and cell-mediated immunity are crucial.
 **Quick Tips**:
  1.Focus on the core mechanism of DNA vaccines: delivery, expression, and immune response.
  2.Remember that VLPs are adjuvants, not essential components.

BALASOURY · Answer

The efficient delivery of the DNA plasmid into host cells.

BALASOURY · Answer

The expression of viral antigens by host cells.

BALASOURY · Answer

The activation of both humoral and cell-mediated immune responses.

BALASOURY · Answer

The correct Option is "The inclusion of viral-like particles to enhance antigen presentation."

NEET Zoology MCQs

Select Chapter

Question Tags

NEET Subjects

Our Bots

Company