The Question is from neet-zoology , and it was created by the author K SUNKANNA

Question

A patient experiences an allergic reaction after being stung by a bee.  Which of the following cell types is NOT directly involved in the immediate hypersensitivity response?

K SUNKANNA · Accepted Answer

## CORE INFORMATION
✓ **Answer**: D
## CONCEPT FRAMEWORK
 **Primary Concept**: Immediate Hypersensitivity (Type I Hypersensitivity)
 **Related Topics**: Allergy, IgE antibodies, mast cell degranulation, inflammatory response
 **Prerequisites**: Understanding of immune system cells and their roles in allergic reactions.
## SOLUTION PATHWAY
**Given Information**:
  A patient has an allergic reaction after a bee sting.
  We need to identify the cell type NOT directly involved in the immediate response.
**Method & Steps**:
 1. Understand immediate hypersensitivity:
  Reasoning: Immediate hypersensitivity is mediated by IgE antibodies binding to mast cells and basophils.  This leads to degranulation and release of histamine and other inflammatory mediators.
  Formula/Rule:  None directly applicable.
 2. Analyze the cell types:
  Working: Mast cells and basophils are key players in immediate hypersensitivity due to their IgE receptors. Eosinophils are recruited to the site of inflammation later, contributing to the late-phase reaction. Cytotoxic T lymphocytes (CTLs) are involved in cell-mediated immunity and are not primarily involved in the immediate allergic response.
  Key Point:  The question focuses on the *immediate* response.
 3. Identify the non-participating cell:
  Result: Cytotoxic T lymphocytes (CTLs) are not directly involved in the immediate hypersensitivity response triggered by a bee sting.
  Verification: CTLs are involved in cell-mediated immunity against viruses and other intracellular pathogens, not in immediate allergic reactions.
 ## OPTION ANALYSIS
A :x: Mast cells are key players in releasing histamine and other mediators.
B :x: Basophils also release histamine and contribute to the immediate reaction.
C :x: Eosinophils play a role in the late-phase reaction of hypersensitivity.
D ✓: Cytotoxic T lymphocytes are not directly involved in the immediate hypersensitivity response.
 ## LEARNING AIDS
 **Common Mistakes**:
  1.Confusing immediate and delayed hypersensitivity: Remember that CTLs are involved in delayed hypersensitivity, not the immediate type.
  2.Overlooking the role of IgE: IgE antibodies are crucial for initiating the cascade in immediate hypersensitivity.
 **Quick Tips**:
  1.Focus on the key players: Mast cells and basophils are the primary effectors in immediate hypersensitivity.
  2.Remember the timeline:  Eosinophils and other cells are recruited later in the inflammatory process.

K SUNKANNA · Answer

Mast cells

K SUNKANNA · Answer

Basophils

K SUNKANNA · Answer

Eosinophils

K SUNKANNA · Answer

The correct Option is "Cytotoxic T lymphocytes (CTLs)"

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