The Question is from neet-zoology , and it was created by the author T SAILAJA

Question

Which of the following BEST describes the interplay of estrogen and inhibin B during the early to mid-follicular phase of the menstrual cycle?

T SAILAJA · Accepted Answer

## CORE INFORMATION
✓ **Answer**: A
## CONCEPT FRAMEWORK
 **Primary Concept**: Hormonal regulation of the menstrual cycle
 **Related Topics**:  Hypothalamic-pituitary-ovarian axis, feedback mechanisms, follicle development, estrogen and inhibin B functions
 **Prerequisites**: Understanding of the menstrual cycle phases, the roles of GnRH, FSH, LH, estrogen, and inhibin B.
## SOLUTION PATHWAY
**Given Information**:
  The question focuses on the early to mid-follicular phase of the menstrual cycle.
  We need to analyze the interplay between estrogen and inhibin B on FSH and LH secretion.
**Method & Steps**:
 1. Understand the roles of estrogen and inhibin B.
  Reasoning: Estrogen and inhibin B are ovarian hormones that exert feedback on the pituitary gland, influencing FSH and LH secretion.
  Formula/Rule: None directly applicable, but understanding of negative and positive feedback loops is crucial.
 2. Analyze the feedback mechanisms during the early to mid-follicular phase.
  Working: In the early to mid-follicular phase, estrogen levels are relatively low.  Low estrogen levels exert negative feedback primarily on FSH secretion, preventing a surge in FSH. Inhibin B, produced by the growing follicles, also specifically suppresses FSH secretion from the anterior pituitary.
  Key Point: Both estrogen and inhibin B act to prevent premature FSH release, ensuring controlled follicle growth.
 3. Evaluate the options provided.
  Result: Option A accurately describes the interplay: Estrogen exerts negative feedback on FSH, and inhibin B specifically suppresses FSH secretion from the anterior pituitary.
  Verification: Option A aligns with the established understanding of hormonal regulation during the early to mid-follicular phase.
 ## OPTION ANALYSIS
A ✓: Correctly identifies the negative feedback effects of both estrogen and inhibin B on FSH.
B :x: Incorrect; during the early to mid-follicular phase, estrogen levels are too low to stimulate GnRH significantly. Inhibin B doesn't stimulate GnRH.
C :x: Incorrect; Estrogen primarily inhibits FSH during the early to mid-follicular phase; Inhibin B also inhibits FSH, not stimulates it. 
D :x: Incorrect;  Both estrogen and inhibin B exert negative feedback, not positive feedback, on LH during this phase. Positive feedback occurs later in the cycle (during ovulation).
 ## LEARNING AIDS
 **Common Mistakes**:
  1.Confusing the feedback mechanisms of estrogen and inhibin B: Understanding that both primarily exert negative feedback on FSH is crucial.
  2.Applying the information from a different phase of the menstrual cycle: The hormonal interactions vary across phases.
 **Quick Tips**:
  1.Remember the negative feedback loop involving estrogen and inhibin B on FSH during the early to mid-follicular phase.
  2.Visualize the hypothalamic-pituitary-ovarian axis and the feedback loops to understand the interplay of hormones.

T SAILAJA · Answer

The correct Option is "Estrogen exerts negative feedback on FSH, while inhibin B specifically suppresses FSH secretion from the anterior pituitary"

T SAILAJA · Answer

Both estrogen and inhibin B stimulate GnRH release from the hypothalamus

T SAILAJA · Answer

Estrogen promotes LH secretion, while inhibin B promotes FSH secretion

T SAILAJA · Answer

Both estrogen and inhibin B exert positive feedback on LH secretion

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