The Question is from neet-botany biomolecules-biology , and it was created by the author K SURESH KUMAR

Question

The phosphodiester bond linking nucleotides in DNA and RNA involves which carbons of the sugar moiety?

K SURESH KUMAR · Accepted Answer

## CORE INFORMATION
✓ **Answer**: [C]
## CONCEPT FRAMEWORK
	**Primary Concept**: Phosphodiester bond structure in nucleic acids
	**Related Topics**: Nucleotide structure, DNA/RNA chemistry
	**Prerequisites**: Understanding of molecular biology and biochemistry
## SOLUTION PATHWAY
**Given Information**:
		- Nucleotides are the building blocks of DNA and RNA.
		- Each nucleotide contains a sugar (ribose in RNA, deoxyribose in DNA), a phosphate group, and a nitrogenous base.
		- Phosphodiester bonds connect the sugar of one nucleotide to the phosphate group of another.
**Method & Steps**:
	1. Identify the relevant components of a nucleotide.
		Reasoning: The sugar moiety has five carbons numbered from 1' to 5'.
		Formula/Rule: The phosphodiester bond forms between the 3' hydroxyl group of one sugar and the 5' phosphate group of another.
	2. Determine which carbons are involved in the phosphodiester bond.
		Working: The bond is specifically formed between the 3' carbon of one nucleotide and the 5' carbon of the next nucleotide.
		Key Point: This linkage creates the sugar-phosphate backbone of nucleic acids.
	3. Conclude the correct answer based on the carbon positions involved.
		Result: The correct carbon positions are 3' and 5'.
		Verification: The connection between the sugar and the phosphate confirms the bond locations.
 ## OPTION ANALYSIS
[A] :x: [1' and 2' do not participate in the phosphodiester bond.]
[B] :x: [2' and 3' are not the correct carbons involved in the bond.]
[C] ✓: [3' and 5' are the correct carbons involved in forming the phosphodiester bond.]
[D] :x: [4' and 5' do not participate in the phosphodiester bond.]
 ## LEARNING AIDS
	**Common Mistakes**:
		1. Confusing the roles of different carbon atoms in the sugar.
			How to avoid: Always refer to a structural diagram of nucleotides when studying.
		2. Misunderstanding the linkage as involving other carbons.
			How to avoid: Focus on the sugar-phosphate backbone during DNA/RNA synthesis explanations.
	**Quick Tips**:
		1. Remember that nucleotides link at the 3' and 5' positions to form a chain.
		2. Use mnemonics to memorize the order of bases and sugar components.

K SURESH KUMAR · Answer

1' and 2'

K SURESH KUMAR · Answer

2' and 3'

K SURESH KUMAR · Answer

The correct Option is "3' and 5'"

K SURESH KUMAR · Answer

4' and 5'

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