The Question is from neet-botany biotechnology , and it was created by the author B VENKAT

Question

Why is Escherichia coli commonly used in the production of genetically engineered human insulin?

B VENKAT · Accepted Answer

## CORE INFORMATION
✓ **Answer**: [A]
## CONCEPT FRAMEWORK
	**Primary Concept**: Genetic engineering and microbial fermentation
	**Related Topics**: Biotechnology, Microbiology, Insulin production
	**Prerequisites**: Understanding of genetic manipulation techniques and microbial growth conditions
## SOLUTION PATHWAY
**Given Information**:
		- Escherichia coli is a bacterium commonly used in biotechnological applications.
		- The goal is to produce human insulin through genetic engineering.
**Method & Steps**:
	1. Identify the characteristics of E. coli that make it suitable for genetic engineering.
		Reasoning: E. coli can be easily cultured and has a well-understood genetic system, making it a model organism for experiments.
		Formula/Rule: Basic properties of model organisms in biotechnology.
	2. Consider the genetic manipulation techniques available for E. coli.
		Working: E. coli can be transformed with plasmids carrying the human insulin gene, allowing it to produce insulin.
		Key Point: The simplicity and efficiency of transformation techniques in E. coli.
	3. Assess the practical implications of using E. coli in insulin production.
		Result: E. coli can be grown rapidly in large quantities, producing significant yields of insulin at a low cost.
		Verification: Compare yield and cost-effectiveness with other organisms used for insulin production.
## OPTION ANALYSIS
[A] ✓: E. coli is easy to culture and genetically manipulate, making it ideal for producing human insulin through recombinant DNA technology.
[B] :x: E. coli does not produce insulin naturally; it must be genetically engineered to do so.
[C] :x: E. coli does not have a similar genome to humans; it is a prokaryote and lacks many human genes.
[D] :x: While some strains of E. coli may be resistant to antibiotics, this is not a primary reason for its use in insulin production.
## LEARNING AIDS
	**Common Mistakes**:
		1. Confusing natural production with recombinant production: Remember that E. coli needs to be genetically engineered to produce human proteins.
		2. Overestimating the similarity between E. coli and human genomes: Focus on understanding the key differences between prokaryotic and eukaryotic organisms.
	**Quick Tips**:
		1. Remember that model organisms are chosen for their ease of manipulation and rapid growth rates.
		2. Use mnemonic devices to remember the characteristics of effective organisms for genetic engineering.

B VENKAT · Answer

The correct Option is "Easy to culture and genetically manipulate"

B VENKAT · Answer

Produces insulin naturally

B VENKAT · Answer

Has a similar genome to humans

B VENKAT · Answer

Is resistant to antibiotics

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