The Question is from neet-botany molecular-basis-of-inheritance mutations, and it was created by the author Mr. NARESH KUMAR K

Question

Sickle cell anemia is caused by a mutation that substitutes valine for glutamic acid. This is an example of:

Mr. NARESH KUMAR K · Accepted Answer

## CORE INFORMATION
✓ **Answer**: [D]
## CONCEPT FRAMEWORK
	**Primary Concept**: Mutation Types
	**Related Topics**: Genetic mutations, protein synthesis
	**Prerequisites**: Understanding of DNA, RNA, and protein structure
## SOLUTION PATHWAY
**Given Information**:
		The mutation in sickle cell anemia involves a substitution of one amino acid for another in the hemoglobin protein.
		Valine (val) is substituted for glutamic acid (glu) in the beta chain of hemoglobin.
**Method & Steps**:
	1. Identify the type of mutation.
		Reasoning: A missense mutation is characterized by a single nucleotide change that results in the coding of a different amino acid.
		Formula/Rule: The substitution of one amino acid (E) with another (V) indicates a missense mutation.
	2. Confirm that the mutation changes the properties of the protein.
		Working: The change from a hydrophilic (glu) to a hydrophobic (val) amino acid alters the solubility and function of hemoglobin.
		Key Point: This change can lead to significant biological effects, such as sickle-shaped cells.
	3. Conclude the type of mutation.
		Result: The mutation is classified as a missense mutation.
		Verification: The definition matches the mutation described in sickle cell anemia.
 ## OPTION ANALYSIS
[A] :x: Nonsense mutation - This type of mutation introduces a premature stop codon, which is not the case here.
[B] :x: Frameshift mutation - This occurs due to insertions or deletions that disrupt the reading frame, which is not applicable here.
[C] :x: Silent mutation - This results in no change to the amino acid sequence, which does not describe the situation.
[D] ✓: Missense mutation - Correctly describes the substitution of one amino acid for another, leading to functional changes in the protein.
 ## LEARNING AIDS
	**Common Mistakes**:
		1. Confusing missense with nonsense mutations: Ensure to identify whether the mutation changes an amino acid or introduces a stop codon.
		2. Overlooking the impact on protein function: Remember that amino acid substitutions can affect protein properties significantly.
	**Quick Tips**:
		1. Remember the mnemonic "Missense means a mistake in amino acid" to differentiate it from other mutation types.
		2. Review common mutations and their impacts on diseases to reinforce understanding.

Mr. NARESH KUMAR K · Answer

Nonsense mutation

Mr. NARESH KUMAR K · Answer

Frameshift mutation

Mr. NARESH KUMAR K · Answer

Silent mutation

Mr. NARESH KUMAR K · Answer

The correct Option is "Missense mutation"

NEET Botany Molecular Basis of Inheritance Mutations MCQs

Select Topic

Question Tags

Question Tags

Question Tags

Question Tags

NEET Subjects

Our Bots

Company