The Question is from neet-botany molecular-basis-of-inheritance , and it was created by the author K SURESH KUMAR

Question

Which of the following statements regarding histones is INCORRECT?

K SURESH KUMAR · Accepted Answer

## CORE INFORMATION
✓ **Answer**: C
## CONCEPT FRAMEWORK
	**Primary Concept**: Histone structure and function
	**Related Topics**: Chromatin organization, DNA packaging, gene regulation, post-translational modifications
	**Prerequisites**: Basic understanding of amino acids, protein structure, and pH.
## SOLUTION PATHWAY
**Given Information**:
	Multiple-choice question about histone properties.
**Method & Steps**:
	1. Analyze each statement based on known histone characteristics.
	2. Identify the incorrect statement.
	3. Validate the correct answer and explain why other options are incorrect.
## OPTION ANALYSIS
[A] ✓: Histones are rich in basic amino acids like lysine and arginine. These positively charged amino acids facilitate interaction with the negatively charged DNA backbone.
[B] ✓: Due to the abundance of lysine and arginine, histones carry a net positive charge at physiological pH (around 7.4). This positive charge allows them to tightly bind to the negatively charged DNA.
[C] :x: Post-translational modifications of histones can MODIFY their positive charge, not necessarily neutralize it. Modifications like acetylation can reduce the positive charge, while methylation can maintain or even slightly increase it. Phosphorylation introduces a negative charge.  The key is that the effect on charge varies depending on the modification.
[D] ✓: Histones form the core of nucleosomes, around which DNA is wrapped.  A nucleosome core particle consists of an octamer of histones (two each of H2A, H2B, H3, and H4).
## LEARNING AIDS
	**Common Mistakes**:
		1. Assuming all post-translational modifications neutralize charge: Remember that different modifications have different effects on histone charge.
		2. Confusing histones with non-histone proteins: Histones are specific proteins involved in DNA packaging. Other proteins interact with DNA but don't form the nucleosome core.
	**Quick Tips**:
		1. Remember 'HAL' (H2A, H2B, H3, H4, Linker histone H1) for the core histones and the linker histone.
		2. Associate positive charge of histones with negative charge of DNA for easy recall of their interaction.

K SURESH KUMAR · Answer

They are rich in basic amino acids like lysine and arginine.

K SURESH KUMAR · Answer

They have a net positive charge at physiological pH.

K SURESH KUMAR · Answer

The correct Option is "Post-translational modifications of histones neutralize their positive charge."

K SURESH KUMAR · Answer

They form the core of nucleosomes.

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