The Question is from neet-botany molecular-basis-of-inheritance , and it was created by the author B VENKAT

Question

In eukaryotes, the TATA box is a crucial promoter element. Which of the following statements about its function is INCORRECT?

B VENKAT · Accepted Answer

## CORE INFORMATION
✓ **Answer**: [A]
## CONCEPT FRAMEWORK
	**Primary Concept**: Transcription initiation in eukaryotes
	**Related Topics**: Promoter elements, transcription factors, RNA polymerase II
	**Prerequisites**: Basic understanding of eukaryotic gene expression
## SOLUTION PATHWAY
**Given Information**:
	The question asks for the INCORRECT statement about the TATA box.
	We need to evaluate each option based on known functions of the TATA box.
**Method & Steps**:
	1. Evaluate option A: 'It directly recruits RNA polymerase II to the promoter.'
		Reasoning: The TATA box is recognized by TATA-binding protein (TBP), which is part of the TFIID complex. TFIID then recruits other transcription factors and eventually RNA polymerase II.
		Key Point: The TATA box does not directly recruit RNA polymerase II, it does so indirectly via TFIID.
	2. Evaluate option B: 'It is recognized by TATA-binding protein (TBP).'
		Reasoning: This is a well-established function of the TATA box.
	3. Evaluate option C: 'It helps determine the transcription start site.'
		Reasoning: The TATA box's position helps define the approximate transcription start site.
	4. Evaluate option D: 'It is typically located approximately 25-30 base pairs upstream of the transcription start site.'
		Reasoning: This is the typical location of the TATA box in many eukaryotic promoters.
	5. Identify the incorrect statement.
		Result: Option A is the only incorrect statement.
		Verification: All other options are known functions of the TATA box.
 ## OPTION ANALYSIS
[A] ✓: This statement is incorrect because the TATA box is recognized by TATA-binding protein (TBP) which is part of the TFIID complex, and this complex then recruits other transcription factors and RNA polymerase II. Thus, the TATA box doesn't directly recruit RNA polymerase II.
[B] :x: This statement is correct. The TATA box is indeed recognized by TATA-binding protein (TBP).
[C] :x: This statement is correct. The TATA box helps determine the transcription start site.
[D] :x: This statement is correct. The TATA box is typically located 25-30 base pairs upstream of the transcription start site.
 ## LEARNING AIDS
	**Common Mistakes**:
		1.[Error 1]: Thinking the TATA box directly recruits RNA polymerase II. It is an indirect process.
		2.[Error 2]: Confusing the role of TBP and RNA polymerase II in the initiation complex.
	**Quick Tips**:
		1.[Helpful shortcut]: Remember the order: TATA box -> TBP -> TFIID -> other transcription factors -> RNA polymerase II.
		2.[Memory aid]: Think of the TATA box as a 'landing pad' for the TBP, not the RNA polymerase directly.

B VENKAT · Answer

The correct Option is "It directly recruits RNA polymerase II to the promoter."

B VENKAT · Answer

It is recognized by TATA-binding protein (TBP).

B VENKAT · Answer

It helps determine the transcription start site.

B VENKAT · Answer

It is typically located approximately 25-30 base pairs upstream of the transcription start site.

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