Prepare for NEET Biology Molecular Basis of Inheritance with MCQs & PYQs on NEET.GUIDE. Access free practice, previous year questions, and expert explanations of DNA replication and genetics.
Wobble base pairing allows a single tRNA to recognize multiple codons. Which position of the codon exhibits the MOST flexibility in wobble pairing?
First base
Second base
Third base
All bases exhibit equal flexibility
During translation, a tRNA molecule carrying a specific amino acid recognizes the corresponding codon on the mRNA through its anticodon. A mutation occurs in the anticodon loop of a tRNA specific for alanine, changing it from 3'-CGI-5' to 3'-CCI-5'. Assuming the wobble hypothesis applies, what is the MOST LIKELY consequence of this mutation?
The tRNA will no longer recognize any codons.
The tRNA will insert glycine into the polypeptide chain instead of alanine.
The tRNA will still carry alanine but will recognize different alanine codons.
The mutation will have no effect on protein synthesis.
A researcher is studying translation in a prokaryotic cell. They introduce a modified mRNA where all the guanine nucleotides in the coding sequence are replaced with inosine. Which of the following is the MOST LIKELY effect on translation?
Translation will terminate prematurely due to the presence of inosine.
The ribosome will be unable to bind to the modified mRNA.
The protein synthesized will be identical to the one produced from the unmodified mRNA.
The protein synthesized will have altered amino acid sequence due to changes in codon recognition.
The wobble hypothesis explains:
The universality of the genetic code.
The non-overlapping nature of the genetic code.
The degeneracy of the genetic code, particularly at the third base of a codon.
The mechanism of frameshift mutations.
