The Question is from neet-botany , and it was created by the author D VINOD

Question

Histone H1 plays a crucial role in the structure of chromatin. Which of the following statements regarding its interaction and function is INCORRECT?

D VINOD · Accepted Answer

## CORE INFORMATION
✓ **Answer**: C
## CONCEPT FRAMEWORK
	**Primary Concept**: Chromatin Structure and Histone Proteins
	**Related Topics**: DNA Packaging, Nucleosomes, Gene Regulation
	**Prerequisites**: Basic understanding of DNA and its organization in eukaryotes.
## SOLUTION PATHWAY
**Given Information**:
	The question asks for the INCORRECT statement about Histone H1's role in chromatin structure.
**Method & Steps**:
	1. **Recall the function of Histone H1**:  Histone H1 is known as the 'linker histone'. Its primary function is to bind to the linker DNA between nucleosomes, facilitating higher-order chromatin compaction.
		Reasoning: H1 helps to stabilize the overall chromatin fiber.
	2. **Analyze each option based on H1's function**:
		Working: Consider how each option relates to the linker histone's role.
		Key Point: H1 is external to the nucleosome core.
	3. **Identify the incorrect statement**:
		Result: Option C states that H1 interacts with the core histones *within* the nucleosome octamer. This is incorrect.
		Verification: H1 binds to the linker DNA *outside* the nucleosome core, not within it.
## OPTION ANALYSIS
[A] ✓: H1 does bind to the linker DNA between nucleosomes. This is a correct statement.
[B] ✓: H1 does help to compact chromatin structure by bringing nucleosomes closer together. This is a correct statement.
[C] :x: H1 does NOT interact with the core histones *within* the nucleosome octamer. It binds to the linker DNA outside the nucleosome. This is the incorrect statement.
[D] ✓: H1 does stabilize the interaction of DNA with the nucleosome by securing the linker DNA. This is a correct statement.
## LEARNING AIDS
	**Common Mistakes**:
		1. Confusing H1 with core histones: Remember H1 is external to the nucleosome, while core histones (H2A, H2B, H3, H4) form the octamer within.
		2. Misunderstanding H1's role in compaction: H1 isn't directly involved in DNA winding around the core histones; it brings nucleosomes together for higher-order compaction.
	**Quick Tips**:
		1. Remember 'L' for Linker: H1 is the 'Linker' histone, binding to 'Linker' DNA.
		2. Visualize H1 as a 'clamp': It clamps the DNA onto the nucleosome, stabilizing the structure.

D VINOD · Answer

H1 binds to the linker DNA between nucleosomes.

D VINOD · Answer

H1 helps to compact chromatin structure.

D VINOD · Answer

The correct Option is "H1 interacts with the core histones within the nucleosome octamer."

D VINOD · Answer

H1 stabilizes the interaction of DNA with the nucleosome.

NEET Botany MCQs

Select Chapter

Question Tags

Question Tags

Question Tags

Question Tags

Question Tags

Question Tags

Question Tags

Question Tags

Question Tags

Question Tags

NEET Subjects

Our Bots

Company