The Question is from neet-zoology chemical-coordincation-and-integration , and it was created by the author BALASOURY

Question

A patient exhibits symptoms of acromegaly.  Which of the following hormonal profiles is MOST consistent with this diagnosis?

BALASOURY · Accepted Answer

## CORE INFORMATION
✓ **Answer**: C
## CONCEPT FRAMEWORK
 **Primary Concept**: Acromegaly and its hormonal markers
 **Related Topics**: Growth hormone (GH), Insulin-like growth factor 1 (IGF-1), Glucose suppression test
 **Prerequisites**: Understanding of endocrine system function and feedback loops.
## SOLUTION PATHWAY
**Given Information**:
  Symptoms consistent with acromegaly.
  Four options describing different GH and IGF-1 levels.
**Method & Steps**:
 1. Understand Acromegaly:
  Acromegaly is caused by excessive secretion of growth hormone (GH), usually due to a pituitary adenoma. This leads to increased levels of IGF-1.
  Reasoning: The hallmark of acromegaly is persistently elevated GH levels.
 2. Glucose Suppression Test:
  A key diagnostic test for acromegaly is the oral glucose tolerance test.  Normally, an oral glucose load suppresses GH secretion.  However, in acromegaly, GH levels remain elevated or only minimally suppressed due to the autonomous GH production from the adenoma.
  Working: Options are evaluated based on their consistency with this test.
 3. Evaluate Options:
  Option C describes elevated GH levels that do not suppress with glucose administration, which perfectly matches the pathophysiology of acromegaly.
  Result: Option C is the most consistent hormonal profile with acromegaly.
  Verification: The other options represent scenarios where GH levels are low or appropriately suppressed by glucose, inconsistent with acromegaly.
 ## OPTION ANALYSIS
A :x: Low GH levels and elevated IGF-1 levels are inconsistent with acromegaly.  Acromegaly is characterized by *high* GH levels.
B :x: Elevated GH levels that *suppress* normally with glucose administration is characteristic of normal physiology, not acromegaly.
C ✓: Elevated GH levels that do not suppress with glucose administration is the defining characteristic of acromegaly.
D :x: Low GH levels and low IGF-1 levels suggest GH deficiency, the opposite of acromegaly.
 ## LEARNING AIDS
 **Common Mistakes**:
  1.Confusing acromegaly with other endocrine disorders:  Understanding the specific hormonal profile is crucial to differentiate acromegaly from other conditions involving GH or IGF-1.
  2.Overlooking the importance of the glucose suppression test: This test is pivotal in diagnosing acromegaly.
 **Quick Tips**:
  1.Remember that in acromegaly, GH levels are high and do not suppress with glucose.
  2.Associate acromegaly with the characteristic features like enlarged hands, feet, and facial features.

BALASOURY · Answer

Low GH levels and elevated IGF-1 levels

BALASOURY · Answer

Elevated GH levels that suppress normally with glucose administration

BALASOURY · Answer

The correct Option is "Elevated GH levels that do not suppress with glucose administration"

BALASOURY · Answer

Low GH levels and low IGF-1 levels

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