The Question is from neet-botany molecular-basis-of-inheritance , and it was created by the author NISHANTH

Question

During transcription elongation in eukaryotes, which of the following is NOT a function of the C-terminal domain (CTD) of RNA polymerase II?

NISHANTH · Accepted Answer

## CORE INFORMATION
✓ **Answer**: A
## CONCEPT FRAMEWORK
 **Primary Concept**: RNA polymerase II C-terminal domain (CTD) function in transcription elongation.
 **Related Topics**: Transcription, RNA processing, mRNA maturation, DNA repair.
 **Prerequisites**: Understanding of eukaryotic transcription, RNA polymerase II structure and function, and the process of mRNA processing.
## SOLUTION PATHWAY
**Given Information**:
The question asks to identify a function NOT performed by the CTD of RNA polymerase II during transcription elongation in eukaryotes.
**Method & Steps**:
1. Analyze the roles of the CTD of RNA polymerase II.
  Reasoning: The CTD is a crucial regulatory element that interacts with various factors involved in transcription and RNA processing.
  Formula/Rule: N/A
2. Evaluate each option's validity.
  Working: Let's examine each option:
  a. Recruiting DNA polymerase for DNA repair during transcription:  The CTD's primary role is in transcription, not DNA repair. DNA repair is a separate process involving distinct enzymes.
  b. Coordinating capping of the 5' end of the pre-mRNA: The CTD interacts with capping enzymes.
  c. Facilitating splicing of the pre-mRNA: The CTD interacts with splicing factors.
  d. Recruiting factors for polyadenylation of the 3' end of the pre-mRNA: The CTD interacts with polyadenylation factors.
  Key Point: The CTD acts as a scaffold, recruiting various factors sequentially during transcription elongation.
3. Identify the incorrect option.
  Result: Option A is incorrect because the CTD does not recruit DNA polymerase for DNA repair.  This is handled by separate repair mechanisms.
  Verification: The other options correctly describe established functions of the CTD.
 ## OPTION ANALYSIS
A ✓: Recruiting DNA polymerase for DNA repair during transcription is NOT a function of the CTD.  DNA repair is a separate process.
B :x: Coordinating capping is a well-established function of the CTD.
C :x: Facilitating splicing is a well-established function of the CTD.
D :x: Recruiting factors for polyadenylation is a well-established function of the CTD.
 ## LEARNING AIDS
 **Common Mistakes**:
  1.Confusing the CTD's role with other processes like DNA repair: Focus on the CTD's specific involvement in transcription and RNA processing.
  2.Assuming all factors involved in transcription are directly linked to the CTD: Remember that the CTD is a key player but not the only one involved.
 **Quick Tips**:
  1.Memorize the main functions of the CTD (capping, splicing, polyadenylation).
  2.Understand that the CTD acts as a platform for coordinating RNA processing events.

NISHANTH · Answer

The correct Option is "Recruiting DNA polymerase for DNA repair during transcription"

NISHANTH · Answer

Coordinating capping of the 5' end of the pre-mRNA

NISHANTH · Answer

Facilitating splicing of the pre-mRNA

NISHANTH · Answer

Recruiting factors for polyadenylation of the 3' end of the pre-mRNA

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