The Question is from neet-zoology , and it was created by the author T SAILAJA

Question

Changes in $\,{\rm{GnRH}}$ pulse frequency in females is controlled by circulating levels of:

T SAILAJA · Accepted Answer

## CORE INFORMATION
✓ **Answer**: A
## CONCEPT FRAMEWORK
**Primary Concept**: Hormonal control of GnRH pulse frequency in females
**Related Topics**: Female reproductive endocrinology, hypothalamic-pituitary-gonadal (HPG) axis, feedback mechanisms
**Prerequisites**: Basic understanding of the HPG axis and the roles of estrogen, progesterone, and inhibin.
## SOLUTION PATHWAY
**Given Information**:
* Question asks about the factors controlling GnRH pulse frequency in females.
* Options list different combinations of reproductive hormones.
**Method & Steps**:
1. **Recall the HPG axis**: GnRH is released from the hypothalamus, which stimulates the release of LH and FSH from the anterior pituitary. These hormones act on the ovaries to regulate the release of sex steroids (estrogen and progesterone). 
Reasoning: The question is directly asking about the hormones involved in the feedback loop that modulates GnRH.
2. **Understand the feedback mechanisms:** Estrogen and progesterone have both positive and negative feedback effects on GnRH release, depending on their levels and the phase of the menstrual cycle. Inhibin primarily has a negative feedback effect on FSH release from the pituitary, not directly on GnRH pulse frequency.
Working:  Estrogen and progesterone levels change during the menstrual cycle, leading to changes in GnRH pulse frequency.
3. **Identify the correct combination:** Based on the understanding of the feedback loops, the correct combination is estrogen and progesterone.
Result: Estrogen and progesterone are the primary hormones involved in regulating GnRH pulse frequency.
Verification:  This is a well-established physiological mechanism.
 ## OPTION ANALYSIS
[A] ✓: Estrogen and progesterone are the primary hormones that regulate GnRH pulse frequency via feedback mechanisms.
[B] :x: Inhibin primarily regulates FSH release from the pituitary, not directly GnRH pulse frequency.
[C] :x: While progesterone is involved, it is not the only hormone. Estrogen also plays a crucial role.
[D] :x: Inhibin does not directly control GnRH pulse frequency. Progesterone alone is insufficient.
 ## LEARNING AIDS
**Common Mistakes**:
1. **Confusing inhibin's role**: Inhibin primarily targets FSH release, not GnRH pulse frequency.
How to avoid: Remember that inhibin acts on the pituitary, not the hypothalamus.
2. **Overlooking the importance of both estrogen and progesterone**: Both hormones are key players in the feedback loops regulating GnRH.
How to avoid:  Understand the combined roles of estrogen and progesterone in the menstrual cycle.
**Quick Tips**:
1. **HPG Axis**: Visualize the HPG axis to understand the hormonal interactions.
2. **Feedback Loops**:  Remember that reproductive hormone levels can have both positive and negative feedback effects on GnRH release.

T SAILAJA · Answer

The correct Option is "Estrogen and progesterone"

T SAILAJA · Answer

Estrogen and inhibin

T SAILAJA · Answer

Progesterone only

T SAILAJA · Answer

Progesterone and inhibin

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