The Question is from neet-zoology , and it was created by the author A SUBRAMANYAM

Question

Transplantation of tissues/organs fails often due to non-acceptance by the patient’s body. Which type of immune-response is responsible for such rejections?

A SUBRAMANYAM · Accepted Answer

## CORE INFORMATION
✓ **Answer**: [C]
## CONCEPT FRAMEWORK
**Primary Concept**: Immune response and transplant rejection
**Related Topics**: Types of immune responses (cell-mediated, humoral), antigens, MHC molecules
**Prerequisites**: Basic understanding of the immune system and its components.
## SOLUTION PATHWAY
**Given Information**:
  *  Transplant rejection occurs.
  *  We need to identify the type of immune response responsible.
**Method & Steps**:
1. **Understanding the problem**: The question asks about the type of immune response causing transplant rejection. This involves the body identifying the transplanted tissue/organ as foreign.
Reasoning: This is a process of immune recognition and attack.
2. **Analyzing the options**: 
    * **Physiological immune response**: This is a broad term and not specific to rejection.
    * **Autoimmune response**: This is when the body attacks its own tissues, not a transplanted one.
    * **Cell-mediated immune response**: This involves T-cells directly attacking foreign cells, matching the description of transplant rejection.
    * **Hormonal immune response**: Hormones can influence immunity but are not the primary mechanism of rejection.
Reasoning: Cell-mediated immunity is the primary immune response responsible for graft rejection.
3. **Final step**: Based on the analysis, cell-mediated immunity is the correct answer.
Result: Cell-mediated immune response.
Verification: Knowledge of basic immunology confirms that T-cells are the main drivers of graft rejection.
## OPTION ANALYSIS
[A] :x: Physiological immune response is a broad category, not a specific mechanism of rejection.
[B] :x: Autoimmune response involves the body attacking self tissues, not transplanted ones.
[C] ✓: Cell-mediated immune responses are primary in graft rejection as T-cells attack the foreign tissue directly.
[D] :x: Hormonal immune response is not a direct mechanism of transplant rejection.
## LEARNING AIDS
**Common Mistakes**:
1. Confusing autoimmune and alloimmune responses (transplant rejection). Autoimmune attacks self, while alloimmune attacks foreign tissue.
2. Overlooking the role of T cells in cell-mediated immunity. Understanding the specific immune cells involved is critical.
**Quick Tips**:
1. Remember cell-mediated immunity involves T cells directly attacking infected or foreign cells.
2. Associate transplant rejection specifically with cell-mediated immunity due to the involvement of cytotoxic T-cells.

A SUBRAMANYAM · Answer

Physiological immune response

A SUBRAMANYAM · Answer

Autoimmune response

A SUBRAMANYAM · Answer

The correct Option is "Cell-mediated immune response"

A SUBRAMANYAM · Answer

Hormonal immune response

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